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Indeed most AD cases have con-comitant CAA (Ellis et al., 1996; Arvanitakis et al., 2011a),but CAA also increases in extent and severity with ageand is common in older persons without a pathologicdiagnosis of AD. These genes have been identi?ed by both gene expression analysis and in vivoWT p53 binding, although there is a lack of a one-to-one correlation between in vivop53 binding and gene activation by WT p53 [ 103 , 169]. BW isperformed to evaluate kidney function and electrolyte values (especially serum potas-sium).

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